Attenuation of the Progression of Articular Cartilage Degeneration by Inhibition of TGF-β1 Signaling in a Mouse Model of Osteoarthritis

Transforming growth factor beta 1 (TGF-β1) is implicated in osteoarthritis. We therefore studied the role of TGF-β1 signaling in the development of osteoarthritis in a developmental stage-dependent manner. Three different mouse models were investigated. First, the Tgf-β receptor II (Tgfbr2) was spec...

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Udgivet i:Am J Pathol
Main Authors: Chen, Rebecca, Mian, Michelle, Fu, Martin, Zhao, Jing Ying, Yang, Liang, Li, Yefu, Xu, Lin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2015
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4630169/
https://ncbi.nlm.nih.gov/pubmed/26355014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.07.003
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