IL-21–Driven Neoplasms in SJL Mice Mimic Some Key Features of Human Angioimmunoblastic T-Cell Lymphoma

SJL/J mice exhibit a high incidence of mature B-cell lymphomas that require CD4(+) T cells for their development. We found that their spleens and lymph nodes contained increased numbers of germinal centers and T follicular helper (T(FH)) cells. Microarray analyses revealed high levels of transcripts...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Jain, Shweta, Chen, Jing, Nicolae, Alina, Wang, Hongsheng, Shin, Dong-Mi, Adkins, Elisabeth B., Sproule, Thomas J., Leeth, Caroline M., Sakai, Tomomi, Kovalchuk, Alexander L., Raffeld, Mark, Ward, Jerrold M., Rehg, Jerold E., Waldmann, Thomas A., Jaffe, Elaine S., Roopenian, Derry C., Morse, Herbert C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2015
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4630166/
https://ncbi.nlm.nih.gov/pubmed/26363366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.07.021
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