A regulatory cascade hypothesis for mammalian sex determination: SRY represses a negative regulator of male development.
The mammalian Y chromosome carries the SRY gene, which determines testis formation. Here we review data on individuals who are XX but exhibit male characteristics: some have SRY; others do not. We have analyzed three families containing more than one such individual and show that these individuals l...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46301/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8475082/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.8.3368 |
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