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A regulatory cascade hypothesis for mammalian sex determination: SRY represses a negative regulator of male development.

The mammalian Y chromosome carries the SRY gene, which determines testis formation. Here we review data on individuals who are XX but exhibit male characteristics: some have SRY; others do not. We have analyzed three families containing more than one such individual and show that these individuals l...

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Main Authors: McElreavey, K, Vilain, E, Abbas, N, Herskowitz, I, Fellous, M
Format: Artigo
Jezik:Inglês
Izdano: 1993
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC46301/
https://ncbi.nlm.nih.gov/pubmed/8475082
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