A conserved NR5A1-responsive enhancer regulates SRY in testis-determination

Abstract The Y-linked SRY gene initiates mammalian testis-determination. However, how the expression of SRY is regulated remains elusive. Here, we demonstrate that a conserved steroidogenic factor-1 (SF-1)/NR5A1 binding enhancer is required for appropriate SRY expression to initiate testis-determina...

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Hlavní autoři:	Denis Houzelstein, Caroline Eozenou, Carlos F. Lagos, Maëva Elzaiat, Joelle Bignon-Topalovic, Inma Gonzalez, Vincent Laville, Laurène Schlick, Somboon Wankanit, Prochi Madon, Jyotsna Kirtane, Arundhati Athalye, Federica Buonocore, Stéphanie Bigou, Gerard S. Conway, Delphine Bohl, John C. Achermann, Anu Bashamboo, Ken McElreavey
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2024-03-01
Edice:	Nature Communications
On-line přístup:	https://doi.org/10.1038/s41467-024-47162-2
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