Substrate induced allosteric change in the quaternary structure of the spermidine N-acetyltransferase SpeG

The spermidine N-acetyltransferase SpeG is a dodecameric enzyme that catalyzes the transfer of an acetyl group from acetyl-coenzyme A to polyamines such as spermidine and spermine. SpeG has an allosteric polyamine-binding site and acetylating polyamines regulates their intracellular concentrations....

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Veröffentlicht in:J Mol Biol
Hauptverfasser: Filippova, Ekaterina V., Weigand, Steven, Osipiuk, Jerzy, Kiryukhina, Olga, Joachimiak, Andrzej, Anderson, Wayne F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629997/
https://ncbi.nlm.nih.gov/pubmed/26410587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.09.013
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