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Substrate induced allosteric change in the quaternary structure of the spermidine N-acetyltransferase SpeG

The spermidine N-acetyltransferase SpeG is a dodecameric enzyme that catalyzes the transfer of an acetyl group from acetyl-coenzyme A to polyamines such as spermidine and spermine. SpeG has an allosteric polyamine-binding site and acetylating polyamines regulates their intracellular concentrations....

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Filippova, Ekaterina V., Weigand, Steven, Osipiuk, Jerzy, Kiryukhina, Olga, Joachimiak, Andrzej, Anderson, Wayne F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629997/
https://ncbi.nlm.nih.gov/pubmed/26410587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.09.013
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