Inhibition of ErbB3 by a monoclonal antibody that locks the extracellular domain in an inactive configuration

ErbB3 (HER3) is a member of the EGF receptor (EGFR) family of receptor tyrosine kinases, which, unlike the other three family members, contains a pseudo kinase in place of a tyrosine kinase domain. In cancer, ErbB3 activation is driven by a ligand-dependent mechanism through the formation of heterod...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lee, Sangwon, Greenlee, Etienne B., Amick, Joseph R., Ligon, Gwenda F., Lillquist, Jay S., Natoli, Edward J., Hadari, Yaron, Alvarado, Diego, Schlessinger, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629334/
https://ncbi.nlm.nih.gov/pubmed/26460020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518361112
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