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Inhibition of ErbB3 by a monoclonal antibody that locks the extracellular domain in an inactive configuration
ErbB3 (HER3) is a member of the EGF receptor (EGFR) family of receptor tyrosine kinases, which, unlike the other three family members, contains a pseudo kinase in place of a tyrosine kinase domain. In cancer, ErbB3 activation is driven by a ligand-dependent mechanism through the formation of heterod...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4629334/ https://ncbi.nlm.nih.gov/pubmed/26460020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518361112 |
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