Recombinant IFN-α2a-NGR exhibits higher inhibitory function on tumor neovessels formation compared with IFN-α2a in vivo and in vitro

We previously reported that NGR-fused IFN-α2a (IFN-α2a-NGR) exhibited similar biological activities with native IFN-α2a and was well-tolerated in mice, rats and monkeys. In the current study, we evaluated the mechanisms of this fusion protein on angiogenesis and tumor formation. Our data indicated t...

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Vydáno v:Cytotechnology
Hlavní autoři: Li, Weina, Hao, Qiang, He, Liqing, Meng, Jieru, Li, Meng, Xue, Xiaochang, Zhang, Cun, Li, Hong, Zhang, Wei, Zhang, Yingqi
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Netherlands 2014
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4628926/
https://ncbi.nlm.nih.gov/pubmed/24897998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-014-9743-y
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