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Safety evaluation and pharmacokinetics of A novel human tumor necrosis factor-alpha exhibited a higher anti-tumor activity and a lower systemic toxicity
We have previously prepared a prokaryotic expressed TNF-α mutant which exhibited a higher anti-tumor activity and a lower systemic toxicity compared with that of wild type TNF-α in both syngeneic murine tumor models and human tumor xenografts models. For its clinical use as an anti-tumor agent, we e...
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Publicado no: | Anticancer Drugs |
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Main Authors: | , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4266396/ https://ncbi.nlm.nih.gov/pubmed/20166241 |
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