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Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway
BACKGROUND: Insulin degrading enzyme (IDE) is a major protease of amyloid beta peptide (Aβ), a prominent toxic protein in Alzheimer’s disease (AD) pathogenesis. Previous studies suggested that statins promote IDE secretion; however, the underlying mechanism is unknown, as IDE has no signal sequence....
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| Udgivet i: | Mol Neurodegener |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4628355/ https://ncbi.nlm.nih.gov/pubmed/26520569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0054-3 |
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