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Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease

The secretion of proteins that lack a signal sequence to the extracellular milieu is regulated by their transition through the unconventional secretory pathway. IDE (insulin-degrading enzyme) is one of the major proteases of amyloid beta peptide (Aβ), a presumed causative molecule in Alzheimer disea...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Son, Sung Min, Cha, Moon-Yong, Choi, Heesun, Kang, Seokjo, Choi, Hyunjung, Lee, Myung-Shik, Park, Sun Ah, Mook-Jung, Inhee
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4854558/
https://ncbi.nlm.nih.gov/pubmed/26963025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1159375
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