The soluble guanylate cyclase activator cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitus

BACKGROUND: Diabetes mellitus (DM) leads to the development of diabetic cardiomyopathy, which is associated with altered nitric oxide (NO)—soluble guanylate cyclase (sGC)—cyclic guanosine monophosphate (cGMP) signalling. Cardioprotective effects of elevated intracellular cGMP-levels have been descri...

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Detalhes bibliográficos
Publicado no:Cardiovasc Diabetol
Main Authors: Mátyás, Csaba, Németh, Balázs Tamás, Oláh, Attila, Hidi, László, Birtalan, Ede, Kellermayer, Dalma, Ruppert, Mihály, Korkmaz-Icöz, Sevil, Kökény, Gábor, Horváth, Eszter Mária, Szabó, Gábor, Merkely, Béla, Radovits, Tamás
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4628236/
https://ncbi.nlm.nih.gov/pubmed/26520063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-015-0309-x
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