NSAIDs Alter Phosphorylated Forms of AQP2 in the Inner Medullary Tip

Vasopressin increases urine concentration through activation of aquaporin-2 (AQP2) in the collecting duct. Nonsteroidal anti-inflammatory drugs (NSAIDs) block prostaglandin E2 synthesis, and may suppress AQP2 producing a urine concentrating defect. There are four serines in AQP2 that are phosphoryla...

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Bibliographic Details
Published in:PLoS One
Main Authors: Ren, Huiwen, Yang, Baoxue, Molina, Patrick A., Sands, Jeff M., Klein, Janet D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627840/
https://ncbi.nlm.nih.gov/pubmed/26517129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141714
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