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NSAIDs Alter Phosphorylated Forms of AQP2 in the Inner Medullary Tip
Vasopressin increases urine concentration through activation of aquaporin-2 (AQP2) in the collecting duct. Nonsteroidal anti-inflammatory drugs (NSAIDs) block prostaglandin E2 synthesis, and may suppress AQP2 producing a urine concentrating defect. There are four serines in AQP2 that are phosphoryla...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4627840/ https://ncbi.nlm.nih.gov/pubmed/26517129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141714 |
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