Dual Mutation Events in the Haemagglutinin-Esterase and Fusion Protein from an Infectious Salmon Anaemia Virus HPR0 Genotype Promote Viral Fusion and Activation by an Ubiquitous Host Protease

In Infectious salmon anaemia virus (ISAV), deletions in the highly polymorphic region (HPR) in the near membrane domain of the haemagglutinin-esterase (HE) stalk, influence viral fusion. It is suspected that selected mutations in the associated Fusion (F) protein may also be important in regulating...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Fourrier, Mickael, Lester, Katherine, Markussen, Turhan, Falk, Knut, Secombes, Christopher J., McBeath, Alastair, Collet, Bertrand
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627773/
https://ncbi.nlm.nih.gov/pubmed/26517828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142020
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