A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo

The CD4 binding site (CD4bs) on the envelope glycoprotein is a major site of vulnerability that is conserved among different HIV-1 isolates. Many broadly neutralizing antibodies (bNAbs) to the CD4bs belong to the VRC01 class, sharing highly restricted origins, recognition mechanisms and viral escape...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Freund, Natalia T., Horwitz, Joshua A., Nogueira, Lilian, Sievers, Stuart A., Scharf, Louise, Scheid, Johannes F., Gazumyan, Anna, Liu, Cassie, Velinzon, Klara, Goldenthal, Ariel, Sanders, Rogier W., Moore, John P., Bjorkman, Pamela J., Seaman, Michael S., Walker, Bruce D., Klein, Florian, Nussenzweig, Michel C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627763/
https://ncbi.nlm.nih.gov/pubmed/26516768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005238
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