Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics

Cyclin E/Cdk2 kinase activity is frequently deregulated in human cancers, resulting in impaired apoptosis. Here, we show that cyclin E/Cdk2 phosphorylates and stabilizes the pro-survival Bcl-2 family protein Mcl-1, a key cell death resistance determinant to the small molecule Bcl-2 family inhibitors...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Choudhary, Gaurav S., Tat, Trinh T., Misra, Saurav, Hill, Brian T., Smith, Mitchell R., Almasan, Alexandru, Mazumder, Suparna
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627281/
https://ncbi.nlm.nih.gov/pubmed/26219338
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