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Cyclin E induction by genotoxic stress leads to apoptosis of hematopoietic cells
Cyclin E is essential for progression through the G1 phase of the cell cycle and initiation of DNA replication by interacting with, and activating its catalytic partner, the cyclin-dependent kinase 2 (Cdk2). We found a substantial increase in cyclin E mRNA, accompanied by increased production of cyc...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2000
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1189738/ https://ncbi.nlm.nih.gov/pubmed/10851086 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1203623 |
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