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Cyclin E induction by genotoxic stress leads to apoptosis of hematopoietic cells

Cyclin E is essential for progression through the G1 phase of the cell cycle and initiation of DNA replication by interacting with, and activating its catalytic partner, the cyclin-dependent kinase 2 (Cdk2). We found a substantial increase in cyclin E mRNA, accompanied by increased production of cyc...

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Bibliographic Details
Main Authors: Mazumder, Suparna, Gong, Bendi, Almasan, Alexandru
Format: Artigo
Language:Inglês
Published: 2000
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1189738/
https://ncbi.nlm.nih.gov/pubmed/10851086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1203623
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