Proteolytic Cleavage of Cyclin E Leads to Inactivation of Associated Kinase Activity and Amplification of Apoptosis in Hematopoietic Cells

Cyclin E/Cdk2 is a critical regulator of cell cycle progression from G(1) to S in mammalian cells and has an established role in oncogenesis. Here we examined the role of deregulated cyclin E expression in apoptosis. The levels of p50-cyclin E initially increased, and this was followed by a decrease...

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Bibliographic Details
Main Authors: Mazumder, Suparna, Gong, Bendi, Chen, Quan, Drazba, Judith A., Buchsbaum, Jeffrey C., Almasan, Alexandru
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC133664/
https://ncbi.nlm.nih.gov/pubmed/11884622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.7.2398-2409.2002
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