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Influence of 5-N-carboxamide modifications on the thermodynamic stability of oligonucleotides
We have recently shown that the incorporation of modified nucleotides such as 5-N-carboxamide-deoxyuridines into random nucleic acid libraries improves success rates in SELEX experiments and facilitates the identification of ligands with slow off-rates. Here we report the impact of these modificatio...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4627095/ https://ncbi.nlm.nih.gov/pubmed/26438535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv981 |
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