Beyond the one-locus-one-miRNA paradigm: microRNA isoforms enable deeper insights into breast cancer heterogeneity

Here we describe our study of miRNA isoforms (isomiRs) in breast cancer (BRCA) and normal breast data sets from the Cancer Genome Atlas (TCGA) repository. We report that the full isomiR profiles, from both known and novel human-specific miRNA loci, are particularly rich in information and can distin...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Telonis, Aristeidis G., Loher, Phillipe, Jing, Yi, Londin, Eric, Rigoutsos, Isidore
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Computational Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627084/
https://ncbi.nlm.nih.gov/pubmed/26400174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv922
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