Knowledge about the presence or absence of miRNA isoforms (isomiRs) can successfully discriminate amongst 32 TCGA cancer types

Isoforms of human miRNAs (isomiRs) are constitutively expressed with tissue- and disease-subtype-dependencies. We studied 10 271 tumor datasets from The Cancer Genome Atlas (TCGA) to evaluate whether isomiRs can distinguish amongst 32 TCGA cancers. Unlike previous approaches, we built a classifier t...

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Telonis, Aristeidis G., Magee, Rogan, Loher, Phillipe, Chervoneva, Inna, Londin, Eric, Rigoutsos, Isidore
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2017
Предметы:
Computational Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389567/
https://ncbi.nlm.nih.gov/pubmed/28206648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx082
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