PX-12 inhibits the growth of hepatocelluar carcinoma by inducing S-phase arrest, ROS-dependent apoptosis and enhances 5-FU cytotoxicity

Background: 1-methylpropyl 2-imidazolyl disulfide (PX-12), a thioredoxin 1 (Trx1) inhibitor, has been investigated in a number of ancers, but its effectiveness in the treatment of hepatocellular carcinoma (HCC) has not been reported. PX-12 has generated considerable interest in its use in a variety...

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Detalhes bibliográficos
Publicado no:Am J Transl Res
Main Authors: Li, Guang-Zhen, Liang, Hui-Fang, Liao, Bo, Zhang, Lei, Ni, Ya-An, Zhou, Hong-Hao, Zhang, Er-Lei, Zhang, Bi-Xiang, Chen, Xiao-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626415/
https://ncbi.nlm.nih.gov/pubmed/26550453
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