Thioredoxin-1 inhibitor PX-12 induces human acute myeloid leukemia cell apoptosis and enhances the sensitivity of cells to arsenic trioxide

Thioredoxin-1 (Trx-1), an important redox regulatory factor, plays a significant role in drug-induced apoptosis. Here we investigated the effects of the Trx-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) on human acute myeloid leukemia cells (AML) and the sensitivity of cells to arsenic t...

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Detalhes bibliográficos
Main Authors: Tan, Yingxia, Bi, Laixi, Zhang, Peili, Wang, Fule, Lin, Feiyan, Ni, Wuhua, Wu, Jianbo, Jiang, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152037/
https://ncbi.nlm.nih.gov/pubmed/25197347
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