Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9

BACKGROUND: The therapeutic efficacy of arsenic trioxide (As(2)O(3)) in acute myeloid leukemia (AML) is modest, which is partly related to its limited intracellular uptake into the leukemic cells. As(2)O(3) enters cells via the transmembrane protein aquaglyceroporin 9 (AQP9). Azacytidine, a demethyl...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Chau, David, Ng, Karen, Chan, Thomas Sau-Yan, Cheng, Yuen-Yee, Fong, Bonnie, Tam, Sidney, Kwong, Yok-Lam, Tse, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431177/
https://ncbi.nlm.nih.gov/pubmed/25953102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-015-0143-3
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