Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9

BACKGROUND: The therapeutic efficacy of arsenic trioxide (As(2)O(3)) in acute myeloid leukemia (AML) is modest, which is partly related to its limited intracellular uptake into the leukemic cells. As(2)O(3) enters cells via the transmembrane protein aquaglyceroporin 9 (AQP9). Azacytidine, a demethyl...

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Bibliografiset tiedot
Julkaisussa:J Hematol Oncol
Päätekijät: Chau, David, Ng, Karen, Chan, Thomas Sau-Yan, Cheng, Yuen-Yee, Fong, Bonnie, Tam, Sidney, Kwong, Yok-Lam, Tse, Eric
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431177/
https://ncbi.nlm.nih.gov/pubmed/25953102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-015-0143-3
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