Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9

BACKGROUND: The therapeutic efficacy of arsenic trioxide (As(2)O(3)) in acute myeloid leukemia (AML) is modest, which is partly related to its limited intracellular uptake into the leukemic cells. As(2)O(3) enters cells via the transmembrane protein aquaglyceroporin 9 (AQP9). Azacytidine, a demethyl...

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Bibliografiske detaljer
Udgivet i:J Hematol Oncol
Main Authors: Chau, David, Ng, Karen, Chan, Thomas Sau-Yan, Cheng, Yuen-Yee, Fong, Bonnie, Tam, Sidney, Kwong, Yok-Lam, Tse, Eric
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431177/
https://ncbi.nlm.nih.gov/pubmed/25953102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-015-0143-3
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