LSD1n is a H4K20 demethylase regulating memory formation via transcriptional elongation control

We report that a neuron-specific isoform of LSD1, LSD1n, resulting from an alternative splicing event, acquires a novel substrate specificity targeting histone H4 K20 methylation, both in vitro and in vivo. Selective genetic ablation of LSD1n leads to deficits in spatial learning and memory, reveali...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Neurosci
Egile Nagusiak: Wang, Jianxun, Telese, Francesca, Tan, Yuliang, Li, Wenbo, Jin, Chunyu, He, Xin, Basnet, Harihar, Ma, Qi, Merkurjev, Daria, Zhu, Xiaoyan, Liu, Zhijie, Zhang, Jie, Ohgi, Kenny, Taylor, Havilah, White, Ryan R., Macfarlan, Todd S., Pfaff, Samuel L., Rosenfeld, Michael G.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625987/
https://ncbi.nlm.nih.gov/pubmed/26214369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4069
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak