LSD1n is a H4K20 demethylase regulating memory formation via transcriptional elongation control

We report that a neuron-specific isoform of LSD1, LSD1n, resulting from an alternative splicing event, acquires a novel substrate specificity targeting histone H4 K20 methylation, both in vitro and in vivo. Selective genetic ablation of LSD1n leads to deficits in spatial learning and memory, reveali...

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Vydáno v:Nat Neurosci
Hlavní autoři: Wang, Jianxun, Telese, Francesca, Tan, Yuliang, Li, Wenbo, Jin, Chunyu, He, Xin, Basnet, Harihar, Ma, Qi, Merkurjev, Daria, Zhu, Xiaoyan, Liu, Zhijie, Zhang, Jie, Ohgi, Kenny, Taylor, Havilah, White, Ryan R., Macfarlan, Todd S., Pfaff, Samuel L., Rosenfeld, Michael G.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625987/
https://ncbi.nlm.nih.gov/pubmed/26214369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4069
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