Defective Mitophagy in XPA via PARP1 Hyperactivation and NAD+/SIRT1 Reduction

Mitochondrial dysfunction is a common feature in neurodegeneration and aging. We identify mitochondrial dysfunction in xeroderma pigmentosum group A (XPA), a nucleotide excision DNA repair disorder with severe neurodegeneration, in silico and in vivo. XPA deficient cells show defective mitophagy wit...

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Published in:Cell
Main Authors: Fang, Evandro Fei, Scheibye-Knudsen, Morten, Brace, Lear E., Kassahun, Henok, SenGupta, Tanima, Nilsen, Hilde, Mitchell, James R., Croteau, Deborah L., Bohr, Vilhelm A.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625837/
https://ncbi.nlm.nih.gov/pubmed/24813611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.03.026
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