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Defective Mitophagy in XPA via PARP1 Hyperactivation and NAD+/SIRT1 Reduction
Mitochondrial dysfunction is a common feature in neurodegeneration and aging. We identify mitochondrial dysfunction in xeroderma pigmentosum group A (XPA), a nucleotide excision DNA repair disorder with severe neurodegeneration, in silico and in vivo. XPA deficient cells show defective mitophagy wit...
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| Publicado no: | Cell |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4625837/ https://ncbi.nlm.nih.gov/pubmed/24813611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.03.026 |
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