Suppression of Homologous Recombination by insulin-like growth factor-1 inhibition sensitizes cancer cells to PARP inhibitors

BACKGROUND: Impairment of homologous recombination (HR) is found in close to 50 % of ovarian and breast cancer. Tumors with BRCA1 mutations show increased expression of the Insulin-like growth factor type 1 receptor (IGF-1R). We previously have shown that inhibition of IGF-1R results in growth inhib...

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Publicat a:BMC Cancer
Autors principals: Amin, Oreekha, Beauchamp, Marie-Claude, Nader, Paul Abou, Laskov, Ido, Iqbal, Sanaa, Philip, Charles-André, Yasmeen, Amber, Gotlieb, Walter H.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625613/
https://ncbi.nlm.nih.gov/pubmed/26510816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-015-1803-y
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