Inhibition of PI3K-AKT-mTOR pathway sensitizes endometrial cancer cell lines to PARP inhibitors

BACKGROUND: Phosphatase and Tensin homolog (PTEN) is a tumor suppressor gene. Loss of its function is the most frequent genetic alteration in endometrioid endometrial cancers (70–80%) and high grade tumors (90%). We assessed the sensitivity of endometrial cancer cell lines to PARP inhibitors (olapar...

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Bibliografski detalji
Izdano u:BMC Cancer
Glavni autori: Philip, Charles-André, Laskov, Ido, Beauchamp, Marie-Claude, Marques, Maud, Amin, Oreekha, Bitharas, Joanna, Kessous, Roy, Kogan, Liron, Baloch, Tahira, Gotlieb, Walter H., Yasmeen, Amber
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591502/
https://ncbi.nlm.nih.gov/pubmed/28886696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3639-0
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