Crystal Structure of a Human Autoimmune Complex between IgM Rheumatoid Factor RF61 and IgG1 Fc Reveals a Novel Epitope and Evidence for Affinity Maturation

Rheumatoid factors (RF) are autoantibodies that recognize epitopes in the Fc region of immunoglobulin (Ig) G and that correlate with the clinical severity of rheumatoid arthritis (RA). Here we report the X-ray crystal-lographic structure, at 3 Å resolution, of a complex between the Fc region of huma...

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Pubblicato in:J Mol Biol
Autori principali: Duquerroy, Stephane, Stura, Enrico A., Bressanelli, Stéphane, Fabiane, Stella M., Vaney, Marie C., Beale, Dennis, Hamon, Maureen, Casali, Paolo, Rey, Felix A., Sutton, Brian J., Taussig, Michael J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625532/
https://ncbi.nlm.nih.gov/pubmed/17395205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.02.085
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