Crystal Structure of a Human Autoimmune Complex between IgM Rheumatoid Factor RF61 and IgG1 Fc Reveals a Novel Epitope and Evidence for Affinity Maturation

Rheumatoid factors (RF) are autoantibodies that recognize epitopes in the Fc region of immunoglobulin (Ig) G and that correlate with the clinical severity of rheumatoid arthritis (RA). Here we report the X-ray crystal-lographic structure, at 3 Å resolution, of a complex between the Fc region of huma...

詳細記述

保存先:
書誌詳細
出版年:J Mol Biol
主要な著者: Duquerroy, Stephane, Stura, Enrico A., Bressanelli, Stéphane, Fabiane, Stella M., Vaney, Marie C., Beale, Dennis, Hamon, Maureen, Casali, Paolo, Rey, Felix A., Sutton, Brian J., Taussig, Michael J.
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4625532/
https://ncbi.nlm.nih.gov/pubmed/17395205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.02.085
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