Linagliptin Limits High Glucose Induced Conversion of Latent to Active TGFß through Interaction with CIM6PR and Limits Renal Tubulointerstitial Fibronectin

BACKGROUND: In addition to lowering blood glucose in patients with type 2 diabetes mellitus, dipeptidyl peptidase 4 (DPP4) inhibitors have been shown to be antifibrotic. We have previously shown that cation independent mannose-6-phosphate receptor (CIM6PR) facilitates the conversion of latent to act...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gangadharan Komala, Muralikrishna, Gross, Simon, Zaky, Amgad, Pollock, Carol, Panchapakesan, Usha
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624988/
https://ncbi.nlm.nih.gov/pubmed/26509887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141143
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