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Acidic residues in the Hfq chaperone increase the selectivity of sRNA binding and annealing
Hfq facilitates gene regulation by small non-coding RNAs (sRNAs), thereby affecting bacterial attributes such as biofilm formation and virulence. E. coli Hfq recognizes specific U-rich and AAN motifs in sRNAs and target mRNAs, after which an arginine patch on the rim promotes base pairing between th...
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| Publié dans: | J Mol Biol |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4624489/ https://ncbi.nlm.nih.gov/pubmed/26196441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.07.010 |
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