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C-terminal domain of the RNA chaperone Hfq drives sRNA competition and release of target RNA

The bacterial Sm protein and RNA chaperone Hfq stabilizes small noncoding RNAs (sRNAs) and facilitates their annealing to mRNA targets involved in stress tolerance and virulence. Although an arginine patch on the Sm core is needed for Hfq’s RNA chaperone activity, the function of Hfq’s intrinsically...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Santiago-Frangos, Andrew, Kavita, Kumari, Schu, Daniel J., Gottesman, Susan, Woodson, Sarah A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5068269/
https://ncbi.nlm.nih.gov/pubmed/27681631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613053113
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