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Exposing Hidden Alternative Backbone Conformations in X-ray Crystallography Using qFit
Proteins must move between different conformations of their native ensemble to perform their functions. Crystal structures obtained from high-resolution X-ray diffraction data reflect this heterogeneity as a spatial and temporal conformational average. Although movement between natively populated al...
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| Publicado no: | PLoS Comput Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4624436/ https://ncbi.nlm.nih.gov/pubmed/26506617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004507 |
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