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Modeling discrete heterogeneity in X-ray diffraction data by fitting multi-conformers
The native state of a protein is regarded to be an ensemble of conformers, which allows association with binding partners. While some of this structural heterogeneity is retained upon crystallization, reliably extracting heterogeneous features from diffraction data has remained a challenge. In this...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
International Union of Crystallography
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2756169/ https://ncbi.nlm.nih.gov/pubmed/19770508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444909030613 |
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