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Fluorinated Sterols are Suicide Inhibitors of Ergosterol Biosynthesis and Growth in Trypanosoma brucei
Trypanosoma brucei, the causal agent for sleeping sickness, depends on ergosterol for growth. Herein, we describe the effects of a mechanism-based inhibitor, 26-fluorolanosterol (26FL), which converts in vivo to a fluorinated substrate of the sterol C24-methyltransferase essential for sterol methyla...
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| Publicado no: | Chem Biol |
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| Principais autores: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4624405/ https://ncbi.nlm.nih.gov/pubmed/26496686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.08.017 |
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