Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth

Ergosterol biosynthesis and homeostasis in the parasitic protozoan Trypanosoma brucei was analyzed by RNAi silencing and inhibition of sterol C24β-methyltransferase (TbSMT) and sterol 14α-demethylase [TbSDM (TbCYP51)] to explore the functions of sterols in T. brucei growth. Inhibition of the amount...

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Veröffentlicht in:J Lipid Res
Hauptverfasser: Haubrich, Brad A., Singha, Ujjal K., Miller, Matthew B., Nes, Craigen R., Anyatonwu, Hosanna, Lecordier, Laurence, Patkar, Presheet, Leaver, David J., Villalta, Fernando, Vanhollebeke, Benoit, Chaudhuri, Minu, Nes, W. David
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4306687/
https://ncbi.nlm.nih.gov/pubmed/25424002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M054643
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