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A Steric Block in Translation Caused by the Antibiotic Spectinomycin
The widely used antibiotic spectinomycin inhibits bacterial protein synthesis by blocking translocation of messenger RNA and transfer RNAs on the ribosome. Here, we show that in crystals of the Escherichia coli 70S ribosome spectinomycin binding traps a distinct swiveling state of the head domain of...
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| Vydáno v: | ACS Chem Biol |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2007
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4624401/ https://ncbi.nlm.nih.gov/pubmed/17696316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb700100n |
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