Thymidylate synthase expression as a predictive biomarker of pemetrexed sensitivity in advanced non-small cell lung cancer

BACKGROUND: Although it has been suggested that a high level of thymidylate synthase (TYMS) gene expression in malignant tumors is related to reduced sensitivity to the antifolate drug pemetrexed, no direct evidence for such an association has been demonstrated in routine clinical samples from patie...

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Bibliografski detalji
Izdano u:BMC Pulm Med
Glavni autori: Chamizo, Cristina, Zazo, Sandra, Dómine, Manuel, Cristóbal, Ion, García-Foncillas, Jesús, Rojo, Federico, Madoz-Gúrpide, Juan
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623912/
https://ncbi.nlm.nih.gov/pubmed/26502926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12890-015-0132-x
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