Thymidylate synthase expression as a predictive biomarker of pemetrexed sensitivity in advanced non-small cell lung cancer

BACKGROUND: Although it has been suggested that a high level of thymidylate synthase (TYMS) gene expression in malignant tumors is related to reduced sensitivity to the antifolate drug pemetrexed, no direct evidence for such an association has been demonstrated in routine clinical samples from patie...

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Udgivet i:BMC Pulm Med
Main Authors: Chamizo, Cristina, Zazo, Sandra, Dómine, Manuel, Cristóbal, Ion, García-Foncillas, Jesús, Rojo, Federico, Madoz-Gúrpide, Juan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623912/
https://ncbi.nlm.nih.gov/pubmed/26502926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12890-015-0132-x
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