Thymidylate synthase expression as a predictive biomarker of pemetrexed sensitivity in advanced non-small cell lung cancer

BACKGROUND: Although it has been suggested that a high level of thymidylate synthase (TYMS) gene expression in malignant tumors is related to reduced sensitivity to the antifolate drug pemetrexed, no direct evidence for such an association has been demonstrated in routine clinical samples from patie...

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Pubblicato in:BMC Pulm Med
Autori principali: Chamizo, Cristina, Zazo, Sandra, Dómine, Manuel, Cristóbal, Ion, García-Foncillas, Jesús, Rojo, Federico, Madoz-Gúrpide, Juan
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623912/
https://ncbi.nlm.nih.gov/pubmed/26502926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12890-015-0132-x
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