Deficiency of Cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role

Using RA and periodontitis mouse models, we demonstrated that RA and periodontitis share many pathological features, such as deregulated cytokine production, increased immune-cell infiltration, increased expression of Toll-like receptors (TLRs), and enhanced osteoclast activity and bone erosion. We...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:FEBS Lett
Main Authors: Hao, Liang, Zhu, Guochun, Lu, Yun, Wang, Min, Jules, Joel, Zhou, Xuedong, Chen, Wei
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623593/
https://ncbi.nlm.nih.gov/pubmed/25896020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2015.04.008
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