Deficiency of Cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role

Using RA and periodontitis mouse models, we demonstrated that RA and periodontitis share many pathological features, such as deregulated cytokine production, increased immune-cell infiltration, increased expression of Toll-like receptors (TLRs), and enhanced osteoclast activity and bone erosion. We...

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Pubblicato in:FEBS Lett
Autori principali: Hao, Liang, Zhu, Guochun, Lu, Yun, Wang, Min, Jules, Joel, Zhou, Xuedong, Chen, Wei
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623593/
https://ncbi.nlm.nih.gov/pubmed/25896020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2015.04.008
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