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Deficiency of Cathepsin K prevents inflammation and bone erosion in rheumatoid arthritis and periodontitis and reveals its shared osteoimmune role
Using RA and periodontitis mouse models, we demonstrated that RA and periodontitis share many pathological features, such as deregulated cytokine production, increased immune-cell infiltration, increased expression of Toll-like receptors (TLRs), and enhanced osteoclast activity and bone erosion. We...
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| Publicado no: | FEBS Lett |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4623593/ https://ncbi.nlm.nih.gov/pubmed/25896020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2015.04.008 |
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