RASSF6 exhibits promoter hypermethylation in metastatic melanoma and inhibits invasion in melanoma cells

Brain metastasis is a major contributor to cancer mortality, yet, the genetic changes underlying the development of this capacity remain poorly understood. RASSF proteins are a family of tumor suppressors that often suffer epigenetic inactivation during tumorigenesis. However, their epigenetic statu...

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Библиографические подробности
Опубликовано в: :Epigenetics
Главные авторы: Mezzanotte, Jessica J, Hill, Victoria, Schmidt, M Lee, Shinawi, Thoraia, Tommasi, Stella, Krex, Dietmar, Schackert, Gabriele, Pfeifer, Gerd P, Latif, Farida, Clark, Geoffrey J
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2014
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623409/
https://ncbi.nlm.nih.gov/pubmed/25482183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15592294.2014.983361
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